Fioricet
Fioricet is a brand-name combination medication used to treat tension headaches. It contains three active ingredients: butalbital (a barbiturate for relaxation), acetaminophen (a pain reliever), and caffeine (which enhances pain relief and constricts blood vessels). This medication is typically prescribed when over-the-counter options are insufficient for managing moderate to severe headache pain.
Fioricet is a prescription combination medication for tension headaches containing a sedative, pain reliever, and caffeine.
Key facts at a glance
- RxNorm
- 175184
- Generic
- Fioricet
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for the relief of tension headache symptoms, including head pain, pressure, and discomfort. May be used for other types of headache as determined by a healthcare provider.
The butalbital component provides mild sedation and muscle relaxation, acetaminophen addresses pain and fever, and caffeine constricts cerebral blood vessels and enhances the effectiveness of the other ingredients. The three components work synergistically to provide headache relief.
Contains a barbiturate (butalbital) with potential for dependence with prolonged use. Avoid alcohol and other CNS depressants while taking this medication. Risk of liver toxicity from acetaminophen with high doses or prolonged use. May cause drowsiness; use caution when driving or operating machinery. Should not be used by those with certain medical conditions including porphyria, liver disease, or substance abuse history.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy