Fioricet With Codeine
Fioricet With Codeine is a prescription combination medication used to treat tension headaches that haven't responded to other treatments. It combines four active ingredients: butalbital (a barbiturate), acetaminophen (a pain reliever), caffeine, and codeine (an opioid). This medication is typically reserved for patients who need stronger headache relief than standard over-the-counter options can provide.
Fioricet With Codeine is a prescription combination medication for tension headaches that contains a barbiturate, pain reliever, caffeine, and opioid.
Key facts at a glance
- RxNorm
- 217126
- Generic
- Fioricet With Codeine
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats tension headaches (muscle contraction headaches) that don't respond adequately to other pain medications. May also be used for other types of severe headaches as determined by a healthcare provider.
The combination works through multiple mechanisms: acetaminophen inhibits pain signals, codeine binds to opioid receptors to reduce pain perception, butalbital promotes relaxation and reduces anxiety that can accompany headaches, and caffeine enhances the effects of the other ingredients while constricting blood vessels.
Contains codeine, making it a Schedule III controlled substance with risk of dependency. Avoid if pregnant, breastfeeding, or have certain respiratory conditions. High doses or prolonged use can cause liver damage from acetaminophen. May cause drowsiness; avoid alcohol and operating machinery. Use only as prescribed.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy