Flucytosine
Flucytosine is an antifungal medication used to treat serious systemic fungal infections. It works by penetrating fungal cells and converting to a compound that interferes with DNA and protein synthesis. This medication is typically reserved for severe infections like cryptococcal meningitis and is often used in combination with other antifungal agents.
An antifungal medication for treating serious systemic fungal infections, often used alongside other antifungals.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- D01AE21
- RxNorm
- 4451
- Generic
- Flucytosine
- Class
- atc-d01
- Brands
- Ancobon
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of serious systemic fungal infections including cryptococcal meningitis, candidiasis, and chromoblastomycosis. Often used in combination with amphotericin B or fluconazole for enhanced efficacy.
Flucytosine enters fungal cells where it is converted to 5-fluorouracil, which disrupts fungal DNA and RNA synthesis, preventing the fungus from replicating and spreading.
Requires regular blood monitoring due to risk of bone marrow suppression and hepatotoxicity. Should be used with caution in patients with renal impairment. Complete treatment courses are essential to prevent resistance development.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy