Fludrocortisone
Fludrocortisone is a synthetic mineralocorticoid used primarily as replacement therapy in conditions where the adrenal glands do not produce adequate natural corticosteroids, most notably Addison's disease. It works by promoting sodium retention and potassium excretion in the kidneys, helping to maintain proper electrolyte and fluid balance in the body. This medication is almost always used in combination with a glucocorticoid to provide complete adrenal hormone replacement.
Fludrocortisone is a mineralocorticoid used to replace missing adrenal hormones in Addison's disease and related conditions by helping the body retain sodium and excrete potassium.
Key facts at a glance
- ATC
- H02AA02
- RxNorm
- 4452
- Generic
- Fludrocortisone
- Class
- atc-h02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primary uses include adrenal insufficiency (Addison's disease), salt-losing congenital adrenal hyperplasia, and sometimes orthostatic hypotension. It provides essential mineralocorticoid replacement when the adrenal glands cannot produce adequate hormones on their own.
Fludrocortisone acts on the kidneys to increase sodium reabsorption in the distal tubules and collecting ducts while simultaneously increasing potassium excretion. This helps maintain normal blood pressure, electrolyte balance, and fluid volume. It has minimal glucocorticoid activity compared to its mineralocorticoid effects.
Blood pressure and electrolyte levels (especially sodium and potassium) must be monitored regularly. Dosage must be carefully individualized. Common side effects include fluid retention, hypertension, and low potassium. Should not be stopped abruptly as this can precipitate adrenal crisis. Often combined with a glucocorticoid like hydrocortisone for complete adrenal replacement therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy