Flumadine
Flumadine (rimantadine) is an antiviral medication historically used for the treatment and prevention of influenza A virus infections. It belongs to the adamantane class of antivirals and works by inhibiting viral replication. Due to widespread resistance among circulating influenza strains, its clinical use has become limited, and it is not currently recommended as a first-line treatment option.
Flumadine is an antiviral that was used to treat and prevent influenza A infections but is now rarely recommended due to viral resistance.
Key facts at a glance
- RxNorm
- 227249
- Generic
- Flumadine
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Flumadine was used for treatment and prevention of influenza A infections in adults and children. It was indicated for both acute treatment of established illness and prophylaxis following exposure. Current clinical guidelines do not recommend adamantanes due to high resistance rates.
Flumadine is an antiviral agent that interferes with the uncoating of influenza A virus by blocking the M2 ion channel. This prevents viral replication early in the infection cycle.
Many circulating influenza A strains are now resistant to rimantadine and amantadine, limiting clinical usefulness. Resistance can develop during treatment. Common side effects may include gastrointestinal symptoms, insomnia, and dizziness. Not effective against influenza B. Patients should consult current CDC guidance for preferred antiviral options.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy