Forfivo
Forfivo is a brand-name extended-release medication containing bupropion hydrochloride, used to treat major depressive disorder and prevent seasonal affective disorder in adults. It belongs to the norepinephrine-dopamine reuptake inhibitor (NDRI) class of antidepressants, working by affecting neurotransmitters in the brain. This medication is available by prescription only and should be used under medical supervision.
Forfivo is a prescription antidepressant used to treat depression and seasonal affective disorder by affecting brain neurotransmitters.
Key facts at a glance
- RxNorm
- 1232586
- Generic
- Forfivo
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Forfivo is indicated for the treatment of major depressive disorder (MDD) and prevention of seasonal affective disorder (SAD) in adults. It may be prescribed when other treatments have not been effective or appropriate.
Forfivo contains bupropion, which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It works by increasing levels of norepinephrine and dopamine in the brain by preventing their reuptake, helping to restore neurotransmitter balance associated with mood regulation.
Forfivo is contraindicated in patients with seizure disorders, eating disorders, or those undergoing abrupt discontinuation of alcohol or sedatives. Common side effects may include insomnia, dry mouth, headache, and nausea. It may increase risk of suicidal thoughts in young adults, children, and adolescents during initial treatment. Do not crush, split, or chew the extended-release tablets. Always consult a healthcare provider before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy