Fosamprenavir
Fosamprenavir is an HIV-1 protease inhibitor prodrug that is converted to amprenavir in the body. It is used in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and children. The medication works by inhibiting viral protease, preventing the cleavage of viral polyproteins essential for infectious virion formation.
Fosamprenavir is an HIV-1 protease inhibitor antiretroviral used to treat HIV infection in combination with other medications.
Key facts at a glance
- ATC
- J05AE07
- RxNorm
- 358262
- Generic
- Fosamprenavir
- Class
- atc-j05
- Brands
- Lexiva
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in combination with other antiretroviral agents, approved for use in adults and children (typically ages 4 weeks and older). It is used as part of combination antiretroviral therapy (cART).
Fosamprenavir is a prodrug that is hydrolyzed to amprenavir, which competitively inhibits the HIV-1 protease enzyme. This prevents the cleavage of viral polyprotein precursors (gag and gag-pol), resulting in non-infectious immature viral particles that cannot replicate.
Should be used only as part of combination antiretroviral therapy. Contraindicated with certain drugs metabolized by CYP450 enzymes. May cause significant drug interactions and adverse effects including rash, GI symptoms, and metabolic changes. Requires dose adjustment in hepatic impairment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy