Fosfestrol
Fosfestrol is a synthetic estrogen medication used in the treatment of prostate cancer. It belongs to the ATC L02 class of endocrine therapies, specifically hormonal agents. The medication works by utilizing estrogenic effects to suppress testosterone production, which prostate cancer cells often depend on for growth.
Fosfestrol is an estrogen-based hormone therapy used to treat prostate cancer by reducing testosterone levels.
Key facts at a glance
- ATC
- L02AA04
- RxNorm
- 25284
- Generic
- Fosfestrol
- Class
- atc-l02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Fosfestrol is primarily indicated for the treatment of prostate cancer, particularly in cases where androgen deprivation therapy is appropriate. It may be used in metastatic or advanced prostate cancer.
As a synthetic estrogen, fosfestrol acts on the pituitary-hypothalamic axis to suppress luteinizing hormone (LH) secretion, which reduces testicular testosterone production. Additionally, estrogens may have direct effects on prostate cancer cells.
Common side effects include gynecomastia, fluid retention, cardiovascular effects, and gastrointestinal symptoms. Due to its estrogenic nature, it may increase risk of thromboembolic events. Use requires careful benefit-risk assessment, particularly in patients with cardiovascular disease. Close monitoring during treatment is essential.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy