Fusilev
Fusilev (levoleucovorin) is a brand-name folate analog medication used as a chemotherapy support drug. It serves as a rescue agent to reduce toxic effects of methotrexate and enhances the efficacy of 5-fluorouracil in treating certain cancers.
Fusilev is a chemotherapy adjuvant that reduces methotrexate toxicity and improves 5-FU effectiveness in cancer treatment.
Key facts at a glance
- RxNorm
- 804688
- Generic
- Fusilev
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to reduce methotrexate toxicity in patients receiving high-dose methotrexate therapy, and in combination with 5-fluorouracil for the palliative treatment of metastatic colorectal cancer.
Provides reduced folate cofactors that bypass the dihydrofolate reductase enzyme blocked by methotrexate, allowing normal cellular metabolism. In 5-FU regimens, it enhances 5-FU's inhibition of thymidylate synthase.
Must be administered only after methotrexate exposure, not before or concurrently. Requires careful monitoring of renal function and blood counts. Should not be used for pernicious anemia or other megaloblastic anemias caused by folate deficiency. Contraindicated with intrathecal methotrexate.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy