Fuzapladib
Fuzapladib is a leukotriene synthesis inhibitor developed in Japan for the treatment of inflammatory conditions. It works by inhibiting the 5-lipoxygenase enzyme, which reduces the production of leukotrienes involved in inflammatory responses. The medication has been studied primarily for vascular inflammatory conditions such as Takayasu arteritis and has also shown potential in treating inflammatory bowel diseases.
Fuzapladib is an anti-inflammatory medication that inhibits leukotriene synthesis and is used primarily for treating inflammatory vascular conditions.
Key facts at a glance
- RxNorm
- 2632642
- Generic
- Fuzapladib
- Class
- unclassified
- Brands
- Panoquell
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Fuzapladib has been investigated primarily for the treatment of vasculitis, particularly Takayasu arteritis, a condition involving inflammation of large blood vessels. It has also been studied for inflammatory bowel diseases such as ulcerative colitis. The medication received approval in Japan for certain inflammatory conditions.
Fuzapladib inhibits the 5-lipoxygenase enzyme, which plays a key role in the synthesis of leukotrienes from arachidonic acid. By reducing leukotriene production, the medication decreases inflammatory responses mediated by these lipid signaling molecules, helping to control inflammation in affected tissues.
Fuzapladib is not approved for use in the United States and is primarily available in Japan. As an anti-inflammatory agent, it may interact with other medications affecting the inflammatory pathway. Patients should consult healthcare providers regarding its availability, appropriate use, and potential side effects in their specific region.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy