Gamifant
Gamifant (emapalumab) is a monoclonal antibody medication that targets and neutralizes interferon gamma (IFN-γ), a key inflammatory cytokine. It is specifically indicated for the treatment of primary hemophagocytic lymphohistiocytosis (HLH) in adult and pediatric patients, including newborns, when conventional HLH therapy is inadequate or not tolerated.
Gamifant is an immunotherapy used to treat primary HLH by blocking interferon gamma, a major driver of the overactive immune response in this rare condition.
Key facts at a glance
- RxNorm
- 2104612
- Generic
- Gamifant
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of primary hemophagocytic lymphohistiocytosis (HLH), a rare and potentially fatal hyperinflammatory disorder, in adult and pediatric patients (including newborns) when standard HLH therapies are insufficient or not tolerated.
Gamifant is a monoclonal antibody that binds to and neutralizes interferon gamma (IFN-γ), a cytokine that plays a central role in driving the excessive inflammatory response seen in HLH. By blocking IFN-γ activity, it helps reduce the hyperinflammatory state characteristic of the disease.
Administered as an intravenous infusion, typically every 3-4 days. Due to increased infection risk during treatment, prophylactic antibiotics for Pneumocystis jirovecii pneumonia and antiviral prophylaxis are recommended. Patients should be monitored closely for signs of infections. May cause infusion-related reactions.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy