Garadacimab
Garadacimab is a monoclonal antibody that inhibits activated Factor XII (FXIIa), targeting the contact activation pathway involved in inflammatory and coagulation processes. It is being developed for the prevention of hereditary angioedema (HAE) attacks, a condition characterized by recurrent episodes of severe swelling.
Garadacimab is a novel FXII inhibitor monoclonal antibody being investigated for hereditary angioedema prophylaxis.
Key facts at a glance
- ATC
- B06AC07
- RxNorm
- 2717169
- Generic
- Garadacimab
- Class
- atc-b06
- Brands
- Andembry
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Hereditary angioedema (HAE) - a rare genetic disorder causing recurrent episodes of painful swelling in various body parts due to dysregulation of the bradykinin pathway
Binds to the catalytic domain of activated Factor XII (FXIIa and βFXIIa), inhibiting its enzymatic activity and thereby blocking the contact activation pathway that leads to bradykinin production and inflammation
As a novel FXII inhibitor, garadacimab represents a new therapeutic approach targeting the upstream contact activation system. Clinical trials were underway to evaluate its efficacy and safety profile for prophylactic use in HAE patients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy