Pralsetinib
Gavreto is a prescription brand-name medication classified as a RET (rearranged during transfection) inhibitor. It is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) and certain types of RET-altered thyroid cancers. This is a targeted therapy that requires genetic testing to confirm the presence of RET alterations before treatment.
Gavreto is a targeted therapy for certain lung and thyroid cancers with RET genetic alterations.
Key facts at a glance
- RxNorm
- 2394942
- Generic
- Gavreto
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Gavreto is used to treat adults with metastatic RET fusion-positive non-small cell lung cancer (NSCLC) and RET-mutant medullary thyroid cancer (MTC) or RET fusion-positive thyroid cancer that requires systemic therapy.
Gavreto works as a RET kinase inhibitor by blocking the activity of RET kinases, which are proteins involved in cell growth. When RET genes are altered or fused with other genes, they can drive cancer cell proliferation. By inhibiting these kinases, Gavreto helps slow or stop cancer growth.
Gavreto is a targeted therapy that requires confirmation of RET gene alterations through genetic testing before use. Common side effects may include fatigue, constipation, muscle pain, and high blood pressure. Patients should discuss potential risks, drug interactions, and monitoring requirements with their healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy