Obinutuzumab
Gazyva (obinutuzumab) is a prescription monoclonal antibody that targets and destroys certain white blood cells called B cells. It is used to treat chronic lymphocytic leukemia (CLL) and follicular lymphoma (a type of non-Hodgkin lymphoma).
Gazyva is a monoclonal antibody medication used to treat certain blood cancers by targeting and eliminating abnormal B cells.
Key facts at a glance
- RxNorm
- 1442694
- Generic
- Gazyva
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Gazyva is approved for the treatment of chronic lymphocytic leukemia (CLL) in combination with other chemotherapy medications, and for previously untreated follicular lymphoma in combination with chemotherapy followed by Gazyva alone for maintenance therapy.
Gazyva is a monoclonal antibody that binds to the CD20 protein found on the surface of B cells. By binding to this protein, it helps the immune system recognize and destroy these cells. It works through antibody-dependent cellular cytotoxicity (ADCC), complement-mediated cytotoxicity, and directly inducing cell death.
Gazyva is administered as an intravenous (IV) infusion in a healthcare setting. Common side effects include infusion reactions, fever, cough, nausea, and frequent infections due to low blood cell counts. Patients should be monitored for tumor lysis syndrome, hepatitis B reactivation, and progressive multifocal leukoencephalopathy (PML). Pregnant or breastfeeding patients should not use this medication.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy