Gestrinone
Gestrinone is a synthetic steroid medication primarily used to treat endometriosis, a condition where tissue similar to the uterine lining grows outside the uterus. It works by suppressing estrogen production and blocking progesterone receptors, creating a hormonal environment that inhibits the growth of endometrial tissue. This medication is typically prescribed for women of reproductive age experiencing moderate to severe endometriosis symptoms.
Gestrinone is an antiprogestogenic steroid used to treat endometriosis by suppressing estrogen and blocking progesterone activity.
Key facts at a glance
- ATC
- G03XA02
- RxNorm
- 4792
- Generic
- Gestrinone
- Class
- atc-g03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Gestrinone is primarily indicated for the treatment of endometriosis, including the reduction of associated symptoms such as pelvic pain, dysmenorrhea (painful periods), and dyspareunia (painful intercourse). It may also be considered for other conditions involving progesterone-dependent tissues.
Gestrinone acts as a synthetic steroid with antiprogestogenic and weak androgenic properties. It suppresses estrogen production by inhibiting ovarian function and blocks progesterone receptors in target tissues. This creates a hypoestrogenic hormonal environment that causes endometrial tissue to atrophy, reducing symptoms and lesion progression.
Gestrinone is contraindicated during pregnancy and breastfeeding. Common side effects may include acne, oily skin, weight gain, voice changes, and menstrual irregularities. Patients should avoid pregnancy during treatment. It is not approved by the FDA for use in the United States but is available in other countries. Regular monitoring by a healthcare provider is recommended during therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy