Givinostat
DUVYZAT (givinostat) is a histone deacetylase inhibitor prescribed for the treatment of Duchenne muscular dystrophy (DMD) in patients aged 6 years and older. As an HDAC inhibitor, it works by modulating gene expression to potentially reduce muscle inflammation and support muscle function.
Givinostat is an HDAC inhibitor used to treat Duchenne muscular dystrophy by modulating gene expression to support muscle function.
Key facts at a glance
- ATC
- M09AX14
- RxNorm
- 2678889
- Generic
- Givinostat
- Class
- atc-m09
- Brands
- Duvyzat
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
DUVYZAT is indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients 6 years of age and older.
Givinostat inhibits histone deacetylase (HDAC) enzymes, which modulate gene expression. The exact mechanism by which it exerts its therapeutic effects in DMD patients is not fully characterized.
Common adverse effects may include gastrointestinal symptoms. Dosing is based on body weight and must be determined by a healthcare provider. Patients should be monitored for hematological changes and cardiac function during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy