Glasdegib
Glasdegib is an antineoplastic medication used to treat certain types of acute myeloid leukemia (AML) in adult patients, typically administered in combination with low-dose cytarabine. It works by inhibiting the Hedgehog signaling pathway, which is involved in cancer cell growth and survival.
Glasdegib is an oral Hedgehog pathway inhibitor used in combination therapy for acute myeloid leukemia.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01XJ03
- RxNorm
- 2105845
- Generic
- Glasdegib
- Class
- atc-l01
- Brands
- Daurismo
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Glasdegib is indicated for the treatment of newly diagnosed acute myeloid leukemia (AML) in adult patients who are not candidates for intensive induction chemotherapy, used in combination with low-dose cytarabine.
Glasdegib is a small molecule inhibitor that binds to and inhibits Smoothened (SMO), a key transmembrane protein in the Hedgehog signaling pathway. By blocking this pathway, it inhibits tumor cell proliferation and survival in certain hematologic malignancies.
Glasdegib carries a boxed warning for embryo-fetal toxicity and should not be used during pregnancy. Common side effects include anemia, fatigue, hemorrhage, and muscle pain. Regular blood monitoring is required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy