Glycine
Glycine is a non-essential amino acid used as a component in certain medical solutions, particularly irrigating fluids and infusion preparations. In the context of blood substitutes and perfusion solutions (ATC B05), it serves as an osmotically active component that helps maintain fluid balance during certain surgical and medical procedures.
An amino acid used in medical solutions to help maintain fluid balance during specific procedures.
Key facts at a glance
- ATC
- B05BA01
- RxNorm
- 4845
- Generic
- Glycine
- Class
- atc-b05
- Brands
- Freamine III 10, Clinimix E 4.25/10, Aminosyn II 8.5 % with Electrolytes, Sulfite-Free, Aminosyn 8.5 % with Electrolytes, Sulfite-Free, Trophamine 10 %, Trophamine 6 %, Plenamine, Prosol, PremaSol, Aminosyn II 15%, Aminosyn II 8.5 %, Sulfite-Free, Aminosyn II 10 %, Aminosyn-HBC 7 %, Sulfite-Free, Aminosyn-PF 10 %, Sulfite-Free, Clinimix E 4.25/5
- Availability
- otc
- Pregnancy
- C
- Lactation
- unknown
- Half-life (h)
- 1.5
- Onset (min)
- 30
- Duration (h)
- 4
- Routes
- oral, intravenous
- Forms
- oral powder, oral capsule, oral tablet, intravenous solution, irrigation solution
- Regions
- United States, Canada, European Union, United Kingdom, Australia, Japan, China
- Monitoring
- serum electrolytes, liver function tests, renal function, plasma ammonia
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteruse under medical supervision
glycine may be used in parenteral nutrition during pregnancy when nutritional support is required
regular maternal and fetal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second third trimesterstandard dosing
used in parenteral nutrition when oral intake is not possible
standard prenatal monitoring
lactation
breastfeedingstandard dosing
glycine is a naturally occurring amino acid excreted in breast milk
no specific monitoring required
pediatric_age
neonatesage-appropriate formulations available
used in pediatric parenteral nutrition formulations such as trophamine
monitor growth parameters and amino acid levels
pediatric_age
infants childrenweight-based dosing
used in parenteral nutrition for pediatric patients when oral intake is insufficient
monitor growth and nutritional status
geriatric
elderlystandard dosing
used in parenteral nutrition for elderly patients requiring nutritional support
monitor renal function and fluid balance
renal_impairment
mild moderateadjust based on renal function
monitor amino acid levels and renal function
regular monitoring of bUN creatinine and amino acid levels
Use with caution and monitor for adverse effects.
hepatic_impairment
cirrhosisstandard dosing
used in parenteral nutrition for patients with hepatic impairment
monitor liver function tests and ammonia levels
Statistics and clinical data
Drug class
Classification of amino acid infusion solutions
Common uses
Therapeutic applications for amino acid injections
Commonly prescribed since
Historical prescribing information
Administration route
Route of administration for parenteral amino acid solutions
Used as a component in irrigating solutions for certain surgical procedures and as part of some parenteral nutrition and infusion formulations where amino acid supplementation is needed.
Functions as an osmotically active substance that helps maintain fluid balance and provides amino acid support. As an inhibitory neurotransmitter, it also plays a role in nerve signal regulation in the central nervous system.
Generally well-tolerated when used appropriately in medical formulations. Should be administered only under healthcare supervision as part of designated medical solutions. Individual tolerance and specific clinical context determine appropriateness of use.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy