Glycopyrronium
Glycopyrronium is an anticholinergic medication used to treat hyperhidrosis (excessive sweating) by blocking the action of acetylcholine on sweat glands. It is available in topical formulations such as cloths and wipes for direct application to affected areas. The medication is typically prescribed when other treatments have not been effective enough.
Glycopyrronium is a topical anticholinergic that reduces excessive sweating by blocking acetylcholine receptors on sweat glands.
Key facts at a glance
- ATC
- D11AA01
- RxNorm
- 1546438
- Generic
- Glycopyrronium
- Class
- atc-d11
- Brands
- Glycate, Robinul, Bevespi, Lonhala, Qbrexza, Glyrx, Breztri, Dartisla, Prevduo, Cuvposa
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- injection, prefilled syringe, inhaler, solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 1mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.5mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.5mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
10 groupspregnancy
first trimesteravoid if possible
use only if benefits outweigh potential risks to fetus
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second third trimesteruse lowest effective dose
use only if clearly needed, monitor for uterine relaxation
fetal growth monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingavoid or discontinue breastfeeding
decision to stop breastfeeding or discontinue drug based on importance of therapy to mother
monitor infant for anticholinergic effects
geriatric
elderly over 65start with lowest dose, titrate slowly
use with extreme caution due to increased sensitivity to anticholinergic effects
monitor for cognitive changes, urinary retention, constipation, dry mouth
Use with caution and monitor for adverse effects.
pediatric_age
children 3 16 yearsweight-based dosing, do not exceed adult doses
approved for pediatric use in drooling (glycopyrrolate oral solution) for cerebral palsy patients age 3-16
monitor growth, hydration status, anticholinergic effects
pediatric_age
infants toddlers under 3not recommended
limited safety and efficacy data in children under 3 years
close monitoring if used off-label
Use with caution and monitor for adverse effects.
renal_impairment
severe renal impairmentreduce dose by 50%, increase dosing interval
use with caution in severe renal impairment (CrCl <30 mL/min)
monitor renal function, adjust dose based on response
Use with caution and monitor for adverse effects.
renal_impairment
moderate renal impairmentdose reduction may be required
use with caution in moderate renal impairment (CrCl 30-50 mL/min)
monitor renal function periodically
Use with caution and monitor for adverse effects.
hepatic_impairment
severe hepatic impairmentuse lowest effective dose
use with caution in severe hepatic impairment
monitor liver function tests
Use with caution and monitor for adverse effects.
alcohol_users
chronic alcohol useavoid excessive alcohol consumption
limit alcohol intake while on glycopyrronium therapy
monitor for increased anticholinergic effects
Use with caution and monitor for adverse effects.
Statistics and clinical data
First FDA approval
Robinul (glycopyrrolate) was the first glycopyrronium product approved by FDA
Drug class
Glycopyrronium belongs to the anticholinergic drug class
Primary therapeutic uses
Common therapeutic applications of glycopyrronium
Brand names
FDA-approved brand names for glycopyrronium products
Glycopyrronium is primarily indicated for the treatment of primary focal hyperhidrosis (excessive sweating) affecting areas such as the underarms, hands, feet, or face. It may be prescribed when conventional antiperspirants have been insufficient to control symptoms.
Glycopyrronium is a competitive antagonist of acetylcholine at muscarinic receptors. By blocking acetylcholine from binding to receptors on eccrine sweat glands, it reduces the nerve signals that stimulate sweat production, thereby decreasing sweat output in treated areas.
Common side effects may include dry mouth, skin dryness or irritation at the application site, and blurred vision if the product contacts the eyes. Patients should wash hands after application and avoid applying near the eyes or mouth. It should be used with caution in patients with certain medical conditions; patients should inform their healthcare provider of their complete medical history before use.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy