Gralise
Gralise is an extended-release formulation of gabapentin, an anticonvulsant medication, primarily used to treat postherpetic neuralgia (PHN)—nerve pain that occurs as a complication of shingles. Its extended-release technology allows for once-daily dosing, providing gradual medication release throughout the day to manage neuropathic pain symptoms.
Gralise is an extended-release gabapentin medication taken once daily to treat nerve pain following shingles (postherpetic neuralgia).
Key facts at a glance
- RxNorm
- 1087976
- Generic
- Gralise
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Gralise is FDA-approved specifically for the treatment of postherpetic neuralgia in adults. It is not approved for seizure management like some other gabapentin formulations. While gabapentin in general may be used off-label for other conditions such as anxiety or insomnia, Gralise should only be used for its approved indication.
Gralise contains gabapentin, which binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of excitatory neurotransmitters involved in pain signal transmission, helping to dampen neuropathic pain responses.
Gralise is taken orally once daily with food, preferably during the evening meal. Dosage is gradually titrated to reduce side effects. Common side effects include dizziness, drowsiness, and peripheral swelling. Patients should not discontinue abruptly. Safety during pregnancy, breastfeeding, and in children has not been established. Alcohol should be avoided as it may enhance side effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy