Gramicidin
Gramicidin is a topical polypeptide antibiotic used primarily in lozenges and throat preparations for treating bacterial infections of the mouth and throat. It is commonly combined with other antimicrobial agents in topical formulations for local treatment only, as systemic absorption is minimal.
Gramicidin is a topical antibiotic used in throat lozenges and local preparations to treat bacterial infections of the throat and mouth.
Key facts at a glance
- ATC
- R02AB30
- RxNorm
- 5011
- Generic
- Gramicidin
- Class
- atc-r02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- ophthalmic
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of bacterial throat infections, pharyngitis, and sore throat when used in lozenge form. Also used in topical eye and ear preparations for localized bacterial infections. Often combined with other antibiotics (such as neomycin and polymyxin B) in multi-agent formulations to broaden the spectrum of activity.
Gramicidin is a polypeptide antibiotic that disrupts bacterial cell membranes by forming ion channels. This causes leakage of cellular contents and bacterial cell death. It is effective primarily against gram-positive bacteria and is used only for local/topical application due to potential toxicity if absorbed systemically.
For topical and local use only—do not use for systemic infections. Not typically used alone; usually combined with other agents for enhanced effectiveness. Safety in pregnancy and breastfeeding should be discussed with a healthcare provider. Should not be used for viral throat infections (e.g., common cold). Allergic reactions are possible in individuals sensitive to gramicidin or related compounds.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy