Grazoprevir
Grazoprevir is a direct-acting antiviral medication used to treat chronic hepatitis C virus (HCV) infection in adults. It is typically administered in combination with elbasvir as the fixed-dose combination product ZEPATIER. This medication targets specific steps in the HCV replication process to help eliminate the virus from the body.
Grazoprevir is an antiviral medication used in combination with elbasvir to treat chronic hepatitis C infection in adults.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- J05AP11
- RxNorm
- 1734630
- Generic
- Grazoprevir
- Class
- atc-j05
- Brands
- Zepatier
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic hepatitis C virus (HCV) infection in adults, specifically indicated for genotypes 1 and 4. Used in patients without cirrhosis or with compensated cirrhosis.
Grazoprevir is a direct-acting antiviral that inhibits the HCV NS3/4A protease enzyme, which is essential for viral replication. By blocking this protease, the medication prevents the virus from multiplying and spreading.
Grazoprevir is always used in combination with elbasvir, not as monotherapy. Baseline testing for HCV NS5A resistance-associated substitutions is recommended before starting treatment. Not recommended for patients with moderate or severe hepatic impairment (Child-Pugh B or C). Must be used with ribavirin in certain patient populations including those with genotype 1a infection or in patients with cirrhosis.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy