Guaiacolsulfonate
Guaiacolsulfonate is an expectorant medication used to help relieve respiratory congestion by loosening and thinning mucus in the airways. It is commonly prescribed for conditions involving excessive or thick respiratory secretions, making it easier for patients to clear their airways through productive coughing.
Guaiacolsulfonate is an expectorant that helps loosen and clear mucus from the respiratory tract in conditions like bronchitis and chest congestion.
Key facts at a glance
- ATC
- R05CA09
- RxNorm
- 636827
- Generic
- Guaiacolsulfonate
- Class
- atc-r05
- Brands
- Hy-KXP
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
12 groupspregnancy
first trimesteravoid if possible
use only if clearly needed, avoid during first trimester unless benefits outweigh risks
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimesteruse lowest effective dose
use only if benefits outweigh risks, consult healthcare provider
routine prenatal care
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse lowest effective dose
avoid close to delivery, use only if necessary
monitor for uterine activity
Use with caution and monitor for adverse effects.
lactation
breastfeedingavoid or discontinue breastfeeding
discontinue breastfeeding or avoid use, consult physician for alternative
monitor infant for unusual symptoms
pediatric_age
under 2 yearsdo not use
not recommended for infants under 2 years due to risk of respiratory depression
respiratory monitoring if exposed
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
2 to 6 yearsreduced dose, use with caution
use only under medical supervision, appropriate pediatric formulation recommended
monitor for adverse effects
Use with caution and monitor for adverse effects.
pediatric_age
6 to 12 yearsdose per weight, do not exceed adult dose
use as directed, pediatric formulation preferred
standard monitoring
Use with caution and monitor for adverse effects.
geriatric
elderlystart with lowest effective dose
standard dosing, monitor renal/hepatic function
monitor renal and hepatic function periodically
renal_impairment
mild renal impairmentno adjustment needed
standard dosing acceptable
routine monitoring
renal_impairment
moderate severe renal impairmentuse with caution, consider dose reduction
use with caution, monitor renal function
monitor renal function more frequently
Use with caution and monitor for adverse effects.
hepatic_impairment
mild hepatic impairmentno adjustment needed
standard dosing acceptable
routine monitoring
hepatic_impairment
moderate severe hepatic impairmentuse with caution
use only if benefits outweigh risks, monitor liver function
monitor liver function tests
Use with caution and monitor for adverse effects.
Statistics and clinical data
Commonly prescribed since
General prescribing information for Guaiacolsulfonate
Drug class
Drug class information for Guaiacolsulfonate
Common uses
Common therapeutic uses
Mechanism of action
Pharmacological mechanism of action
Used to treat respiratory conditions with excessive or thick mucus, including bronchitis, common cold, chest congestion, and other upper respiratory tract infections where expectoration is difficult.
As an expectorant, it works by stimulating the secretion of fluid in the respiratory tract, which helps to thin and loosen thick mucus, making it easier to cough up and clear from the airways.
Should be taken with adequate fluids to enhance its effectiveness. Patients should consult their healthcare provider before use, especially if pregnant, breastfeeding, or taking other medications. Not recommended for chronic productive coughs without medical supervision.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy