Ledipasvir/Sofosbuvir
Harvoni is a prescription medication used to treat chronic hepatitis C virus (HCV) infection in adults and children. It combines two direct-acting antiviral agents that work together to prevent the virus from multiplying and spreading in the body. Treatment typically involves taking one tablet daily for 8-12 weeks, with cure rates exceeding 90% in most patient populations.
Harvoni is a combination antiviral medication used to cure chronic hepatitis C infection by preventing the virus from multiplying in the body.
Key facts at a glance
- RxNorm
- 1591944
- Generic
- Harvoni
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic hepatitis C virus (HCV) infection in adults and children aged 3 years and older. It is specifically indicated for HCV genotypes 1, 4, 5, and 6, and may be used in patients with or without cirrhosis (except those with decompensated cirrhosis).
Harvoni combines two direct-acting antiviral agents: ledipasvir (an NS5A inhibitor) and sofosbuvir (a nucleotide analog inhibitor of NS5B polymerase). These drugs work together to inhibit multiple steps of viral replication - sofosbuvir blocks the enzyme needed for viral RNA copying, while ledipasvir prevents the virus from assembling and spreading to new cells.
Harvoni is contraindicated with certain medications, particularly those containing rifampin or St. John's wort, due to risk of reduced efficacy. Common side effects include fatigue, headache, and nausea. Patients should be monitored for potential hepatitis B reactivation before starting treatment. Regular monitoring of liver function and viral load is typically performed during and after treatment to confirm cure (sustained virologic response).
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy