Doxercalciferol
Hectorol (doxercalciferol) is a synthetic vitamin D analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease, particularly those on dialysis. It works by providing a precursor that the body converts to an active form of vitamin D, helping to regulate parathyroid hormone (PTH), calcium, and phosphorus levels.
Hectorol is a vitamin D analog used to manage secondary hyperparathyroidism in kidney disease patients.
Key facts at a glance
- RxNorm
- 261539
- Generic
- Hectorol
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Hectorol is primarily indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease, especially those undergoing dialysis. It may also be used for parathyroid disorders where vitamin D supplementation is needed to help control PTH levels.
Hectorol contains doxercalciferol, a prodrug that is converted in the liver to 1-alpha-hydroxyvitamin D2. This active metabolite binds to vitamin D receptors, helping to regulate calcium and phosphorus metabolism and suppress excessive parathyroid hormone secretion.
Hectorol can cause hypercalcemia if overused; regular monitoring of serum calcium, phosphorus, and PTH levels is essential during treatment. Patients should inform their healthcare provider of all medications and supplements being taken, as drug interactions may occur. This medication is typically used under the supervision of a nephrologist.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy