Hepatitis B Immune Globulin
Hepagam B is a brand-name hepatitis B immune globulin (HBIG) product that provides passive immunity against the hepatitis B virus. It is primarily used for post-exposure prophylaxis in individuals who have been exposed to hepatitis B, including healthcare workers with needlestick injuries and infants born to HBV-infected mothers. Additionally, it is administered to prevent hepatitis B recurrence in patients undergoing liver transplantation who are hepatitis B positive.
Hepagam B is a hepatitis B immune globulin used to prevent hepatitis B infection after exposure or recurrence after liver transplant.
Key facts at a glance
- RxNorm
- 643799
- Generic
- Hepagam B
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Hepagam B is indicated for post-exposure prophylaxis against hepatitis B virus following accidental exposure (such as needlestick injuries), for prevention of perinatal transmission from HBV-positive mothers to newborns, and for prevention of hepatitis B recurrence in patients receiving liver transplants.
Hepagam B contains hepatitis B immune globulin, which provides passive immunization by supplying ready-made antibodies against the hepatitis B virus. These antibodies help neutralize the virus and provide immediate, though temporary, protection until the recipient's own immune system can potentially develop active immunity.
Hepagam B is administered by intramuscular or intravenous injection and should be given as soon as possible after exposure for optimal effectiveness. It may interfere with the response to certain live vaccines, and vaccination schedules may need adjustment. Common side effects include injection site reactions, headache, and mild fever. It is contraindicated in individuals with severe allergies to human immune globulin products.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy