Hepatitis B Immune Globulin
Hepatitis B Immune Globulin (HBIG) is a blood product containing antibodies against the hepatitis B virus. It provides immediate passive immunity and is used as post-exposure prophylaxis for individuals who have been exposed to hepatitis B, particularly newborns of infected mothers and those with needlestick or sexual exposures. HBIG is typically administered alongside the hepatitis B vaccine for comprehensive protection.
A passive immunization agent providing immediate hepatitis B protection in post-exposure scenarios and for high-risk newborns.
Key facts at a glance
- ATC
- J06BB04
- RxNorm
- 26744
- Generic
- Hepatitis B Immune Globulin
- Class
- atc-j06
- Brands
- Nabi-HB, Hyperhep B, HepaGam B
- Availability
- rx
- Pregnancy
- C
- Lactation
- caution
- Routes
- —
- Forms
- prefilled syringe, injection, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 0.06 mL/kg (approximately 400-500 IU)
- Maximum
- consult physician
- Frequency
- single dose post-exposure
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.06 mL/kg (maximum 500 IU)
- Maximum
- consult physician
- Frequency
- single dose post-exposure
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 0.06 mL/kg (approximately 400-500 IU)
- Maximum
- consult physician
- Frequency
- single dose post-exposure
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
10 groupspregnancy
first trimesternone recommended
use only when clearly needed for post-exposure prophylaxis or if benefits outweigh potential risks
standard prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimesternone recommended
use when needed for exposure or as part of hepatitis B immunization protocol
standard prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesternone recommended
use when indicated for hepatitis B exposure or prevention
standard prenatal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingnone recommended
compatible with breastfeeding - not expected to be absorbed by infant
no specific monitoring required
pediatric_age
neonatalweight-based dosing
used for perinatal hepatitis B prevention - administer to newborns of HBsAg-positive mothers within 12 hours of birth
monitor for hypersensitivity reactions
pediatric_age
pediatricweight-based dosing
used for post-exposure prophylaxis in children following needlestick or sexual exposure
monitor for hypersensitivity reactions
geriatric
elderlynone recommended
use standard dosing based on indication - consider renal and hepatic function
assess renal function before administration
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderatenone recommended
no dose adjustment needed - not primarily renally cleared
standard monitoring
renal_impairment
severenone recommended
use with caution - monitor for fluid overload as product may contain sodium
monitor fluid status and renal function
Use with caution and monitor for adverse effects.
hepatic_impairment
liver diseasenone recommended
used for hepatitis B prophylaxis in liver transplant recipients - standard dosing applies
standard monitoring for transplant patients
Statistics and clinical data
Drug class
Biological product for passive immunization against Hepatitis B
Primary indications
Therapeutic indications for Hepatitis B Immune Globulin
Mechanism of action
Pharmacological mechanism of HBIG
Common brand names
Commercially available Hepatitis B Immune Globulin products
Post-exposure prophylaxis following needlestick injuries or sexual contact with hepatitis B-infected individuals; prevention of perinatal transmission from HBV-positive mothers to newborns; protection for unvaccinated individuals with recent exposure to hepatitis B.
Provides passive humoral immunity by supplying pre-formed antibodies against hepatitis B surface antigen (HBsAg), offering immediate but temporary protection while the body develops active immunity through vaccination.
Administered by intramuscular injection; not a substitute for hepatitis B vaccination (both are often given together); derived from human plasma with potential infectious disease risk; effectiveness diminishes with delayed administration; passive antibodies may interfere with live vaccine response.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy