Hepatitis B Vaccine
The Hepatitis B Surface Antigen Vaccine is an immunization that provides protection against hepatitis B virus infection. The vaccine contains a recombinant protein from the hepatitis B surface antigen that stimulates the immune system to produce protective antibodies. It is recommended for infants, children, and adults at increased risk of hepatitis B exposure, including healthcare workers, individuals with multiple sexual partners, and those traveling to endemic regions.
A vaccine that prevents hepatitis B infection by stimulating the immune system to produce protective antibodies against the hepatitis B virus.
Key facts at a glance
- RxNorm
- 797752
- Generic
- Hepatitis B Surface Antigen Vaccine
- Class
- unclassified
- Brands
- Twinrix, Heplisav-B, Vaxelis, Prehevbrio, PEDIARIX, Engerix-B, Recombivax
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- prefilled syringe, injection, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of hepatitis B virus infection in individuals of all ages. Primary recipients include newborns, infants, children, adolescents, and adults with risk factors such as healthcare work, exposure to blood products, multiple sexual partners, injection drug use, travel to endemic areas, and household contact with infected individuals.
The vaccine contains recombinant hepatitis B surface antigen (HBsAg) protein produced using yeast cells. This protein stimulates the immune system to produce protective antibodies against the hepatitis B virus, conferring active immunity without causing infection. A complete series is required for optimal protection.
Administered as a 2- or 3-dose series depending on the vaccine formulation and recipient age. Common side effects include mild soreness, redness, or swelling at the injection site, and temporary fatigue or headache. The vaccine is contraindicated in individuals with severe allergic reactions to any vaccine component. Blood testing may be recommended after completion of the series to confirm adequate antibody response, particularly in high-risk individuals.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 29, 2026. · Read our editorial policy