Methenamine Hippurate
Hiprex is a urinary antiseptic medication used to prevent and treat recurrent urinary tract infections (UTIs). It contains methenamine hippurate or mandelate, which works by converting to formaldehyde in acidic urine to kill bacteria. This medication is typically prescribed for patients with chronic or recurrent UTIs as a preventive measure or mild treatment option.
Hiprex is a urinary antiseptic used to prevent and treat recurrent urinary tract infections by creating an antibacterial environment in the bladder.
Key facts at a glance
- RxNorm
- 151856
- Generic
- Hiprex
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention and treatment of recurrent urinary tract infections, particularly uncomplicated lower UTIs. Often used for patients who experience frequent bladder infections.
Hiprex contains methenamine, which is hydrolyzed to formaldehyde in acidic urine. The formaldehyde denatures bacterial proteins and nucleic acids, providing antibacterial effects directly in the urinary tract.
Urine must be acidic (pH below 6) for optimal efficacy; ascorbic acid may be prescribed to acidify urine. Not suitable for renal impairment or severe upper UTIs. May cause GI upset and requires adequate hydration. Effectiveness reduced in alkaline urine.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy