Human Vaccinia Immune Globulin
Human Vaccinia Immune Globulin (VIG) is a specialized immune globulin product containing antibodies against the vaccinia virus, derived from plasma of immunized donors. It is used to treat serious complications that may occur following smallpox vaccination with live vaccinia virus. This medication provides passive immunity by neutralizing the virus and modulating the immune response.
A passive immunizing agent used to treat smallpox vaccination complications including eczema vaccinatum and progressive vaccinia.
Key facts at a glance
- ATC
- J06BB07
- RxNorm
- 597392
- Generic
- Human Vaccinia Immune Globulin
- Class
- atc-j06
- Brands
- CNJ-016
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of serious complications following smallpox vaccination, such as eczema vaccinatum, progressive vaccinia, severe generalized vaccinia, and vaccinia keratitis.
Provides passive immunization by supplying pre-formed antibodies against vaccinia virus. These antibodies help neutralize the virus and may modulate the immune response to control infection.
Administered by intramuscular or intravenous injection. Use with caution in individuals with immunoglobulin A deficiency or history of severe allergic reactions to blood products. Efficacy and safety in specific populations should be evaluated by a healthcare provider.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy