Hyaluronate Sodium
Hyalgan is a brand-name injectable medication containing sodium hyaluronate, a substance naturally found in joint fluid. It is used to treat knee pain caused by osteoarthritis in patients who have not responded adequately to conservative non-pharmacologic therapies and simple analgesics like acetaminophen. The medication is administered as a series of injections directly into the knee joint by a healthcare professional.
Hyalgan is an injectable hyaluronic acid supplement used to relieve knee pain in patients with osteoarthritis.
Key facts at a glance
- RxNorm
- 154682
- Generic
- Hyalgan
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of pain in osteoarthritis of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics such as acetaminophen.
Hyalgan is a viscous elastic preparation that supplements the natural hyaluronic acid in the joint fluid, helping to lubricate and cushion the knee joint, which may reduce pain and improve mobility.
Administered as weekly intra-articular injections for 3-5 weeks. Should only be given by a qualified healthcare professional. Contraindicated in patients with known hypersensitivity to hyaluronate preparations or gram-positive bacterial proteins. Use with caution in patients with joint infections or skin diseases in the injection area.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy