Hydroflumethiazide
Hydroflumethiazide is a thiazide diuretic used to treat hypertension and fluid retention (edema) associated with conditions such as heart failure, liver disease, and kidney disorders. It works by increasing the amount of salt and water expelled from the body through urine, which reduces blood volume and lowers blood pressure.
Hydroflumethiazide is a thiazide diuretic that removes excess fluid from the body to treat high blood pressure and edema.
Key facts at a glance
- ATC
- C03AA02
- RxNorm
- 5495
- Generic
- Hydroflumethiazide
- Class
- atc-c03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
first trimesteravoid if possible
use only if benefits outweigh risks
regular fetal monitoring
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid
thiazide diuretics may cause fetal and neonatal jaundice and thrombocytopenia
fetal monitoring and platelet counts
Use with caution and monitor for adverse effects.
lactation
nursing mothersavoid or use lowest effective dose
excreted in breast milk, monitor infant for electrolyte disturbances
monitor infant for signs of dehydration and electrolyte imbalance
Use with caution and monitor for adverse effects.
geriatric
elderlystart with lower dose
increased sensitivity to orthostatic hypotension and electrolyte changes
monitor blood pressure, renal function and electrolytes regularly
Use with caution and monitor for adverse effects.
pediatric_age
childrenweight-based dosing required
not recommended for infants; use with caution in children
frequent monitoring of electrolytes and renal function
Use with caution and monitor for adverse effects.
renal_impairment
moderate to severereduce dose or avoid in severe impairment
less effective when creatinine clearance below 30 mL/min
monitor renal function and electrolytes closely
Use with caution and monitor for adverse effects.
hepatic_impairment
moderate to severeuse with caution
may precipitate hepatic encephalopathy in advanced liver disease
monitor liver function and electrolytes
Use with caution and monitor for adverse effects.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Mechanism of action
Pharmacological action
Treats high blood pressure (hypertension) and fluid retention (edema) caused by conditions such as congestive heart failure, liver cirrhosis, kidney dysfunction, and corticosteroid or estrogen therapy.
As a thiazide diuretic, it inhibits sodium reabsorption in the distal convoluted tubules of the kidneys, promoting increased excretion of sodium, water, and electrolytes including potassium and magnesium.
May cause electrolyte imbalances (low potassium, sodium, magnesium), dehydration, and increased sensitivity to sunlight. Regular blood tests may be needed to monitor kidney function and electrolyte levels. Alcohol and other blood pressure medications may enhance its effects.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy