Hydroquinone
Hydroquinone is a topical skin-lightening agent used to treat hyperpigmentation conditions such as melasma, age spots, freckles, and post-inflammatory hyperpigmentation. It works by reducing melanin production in the skin through inhibition of the tyrosinase enzyme. This medication is typically prescribed for short-term use under medical supervision, often in combination with sun protection measures.
Topical treatment for lightening dark spots and hyperpigmented areas of the skin.
Key facts at a glance
- ATC
- D11AF01
- RxNorm
- unknown
- Generic
- Hydroquinone
- Class
- atc-d11
- Brands
- Neova Complex HQ Plus, Lustra, Tri-Luma, EpiQuin Micro, Remergent HQ
- Availability
- otc
- Pregnancy
- C
- Lactation
- caution
- Half-life (h)
- 0
- Onset (min)
- 0
- Duration (h)
- 0
- Routes
- topical
- Forms
- cream, lotion, gel, solution
- Regions
- United States, Canada, United Kingdom, Australia
- Monitoring
- skin irritation, ochronosis
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats hyperpigmentation disorders including melasma, solar lentigines (age/sun spots), freckles, chloasma, and post-inflammatory hyperpigmentation. Used for uneven skin tone and dark patches on the face and body.
Hydroquinone is a phenolic compound that inhibits the enzyme tyrosinase, which is essential for melanin (skin pigment) synthesis. By reducing melanin production in melanocytes, it lightens hyperpigmented areas of skin over time with regular application.
For topical use only; avoid contact with eyes, mouth, and mucous membranes. Should be used with broad-spectrum sunscreen as sun exposure can worsen pigmentation. Typically recommended for limited treatment periods (2-3 months) to avoid potential side effects like skin irritation or exogenous ochronosis. Contraindicated in pregnancy and breastfeeding. Keep out of reach of children.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy