Hydrotalcite
Hydrotalcite is an antacid that neutralizes excess stomach acid, providing relief from heartburn and other acid-related digestive symptoms.
Hydrotalcite is an antacid that neutralizes stomach acid to relieve heartburn and digestive discomfort.
Key facts at a glance
- ATC
- A02AD04
- RxNorm
- 27221
- Generic
- Hydrotalcite
- Class
- atc-a02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
first trimesteruse lowest effective dose
avoid chronic use; use only for short-term symptom relief when benefits outweigh potential risks
monitor for adverse effects
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse lowest effective dose and shortest duration
avoid high doses and prolonged use; magnesium-aluminum containing antacids may affect fetal development
regular prenatal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment typically required
compatible with breastfeeding; minimal excretion into breast milk expected
no specific monitoring required
pediatric_age
children under 12weight-based dosing; reduce adult dose
use only under medical supervision; avoid prolonged use in children
monitor for constipation or diarrhea, electrolyte balance
Use with caution and monitor for adverse effects.
geriatric
elderly 65start with lower dose, monitor renal function
use with caution due to decreased renal function and risk of electrolyte imbalance; avoid long-term high-dose therapy
monitor renal function, serum electrolytes, magnesium levels
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderatereduce dose and extend dosing interval
use with caution; monitor renal function and electrolytes; avoid in severe renal impairment
regular monitoring of serum creatinine, electrolytes, renal function tests
Use with caution and monitor for adverse effects.
hepatic_impairment
mild to moderateno specific adjustment needed for mild-moderate impairment
generally safe; no dose adjustment required for mild-moderate hepatic impairment
standard clinical monitoring
Statistics and clinical data
Commonly prescribed since
General prescribing information for antacid medications
Drug class
Drug class information for Hydrotalcite
Common uses
Common therapeutic uses of Hydrotalcite
Mechanism of action
How Hydrotalcite works in the body
Treatment of symptoms associated with gastric hyperacidity, including heartburn, acid reflux, sour stomach, and dyspepsia. May also be used as adjunctive therapy in peptic ulcer disease.
Hydrotalcite acts as a buffer and antacid, neutralizing gastric acid in the stomach to raise pH levels. It also forms a protective barrier on the gastric mucosa, helping to shield the stomach lining from acid irritation.
Should be taken as directed, typically after meals or at bedtime. Patients with renal impairment, phosphate deficiency, or on sodium-restricted diets should consult a healthcare provider before use. May affect absorption of other medications if taken simultaneously; spacing doses apart may be necessary. Not intended for long-term use without medical supervision.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy