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Hydroxyzine Hydrochloride

Published: July 26, 2026Updated: August 28, 2026

Hydroxyzine Hydrochloride is a first-generation antihistamine medication that works by blocking histamine H1 receptors in the body. It is primarily used to treat anxiety and tension, relieve itching from allergic conditions, and as a sedative before surgical procedures.

Quick summary

Hydroxyzine Hydrochloride is an antihistamine used for anxiety, allergic itching, and sedation.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 28, 2026Editorial policy

Key facts at a glance

RxNorm
154987
Generic
Hydroxyzine Hydrochloride
Class
pin-variant
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Treats anxiety disorders, allergic skin conditions with itching, pruritus, and provides preoperative sedation. May also be used for nausea and vomiting.

Blocks H1 histamine receptors in the central nervous system and peripheral tissues, reducing allergic reactions and producing a calming sedative effect.

May cause drowsiness; avoid alcohol and operating machinery. Use with caution in patients with glaucoma, urinary retention, or heart conditions. Not recommended during early pregnancy unless clearly needed.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy