Losartan Potassium and Hydrochlorothiazide
Hyzaar is a combination prescription medication used to treat high blood pressure (hypertension) in patients who need multiple agents to achieve adequate control. It combines two different classes of blood pressure medications: an angiotensin II receptor blocker (losartan) and a thiazide diuretic (hydrochlorothiazide), working synergistically to lower blood pressure through complementary mechanisms.
Hyzaar is a two-drug combination used to treat high blood pressure when a single medication is not sufficient.
Key facts at a glance
- RxNorm
- 217681
- Generic
- Hyzaar
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hypertension (high blood pressure) in patients who require combination therapy to achieve blood pressure goals. It is typically prescribed when monotherapy with either component alone does not adequately control blood pressure.
Losartan blocks angiotensin II receptors, preventing blood vessel constriction; hydrochlorothiazide is a thiazide diuretic that helps the kidneys remove excess fluid and salt from the body. Together, they reduce blood volume and relax blood vessels to lower blood pressure.
Should not be used during pregnancy, especially in the second and third trimesters, due to risk of fetal harm. May cause dizziness, dehydration, and electrolyte imbalances. Regular monitoring of kidney function and electrolytes may be needed. Avoid potassium supplements unless directed by a physician.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy