Ibrexafungerp Citrate
Ibrexafungerp Citrate is an oral antifungal medication classified as a triterpenoid that works by inhibiting beta-(1,3)-D-glucan synthase, an enzyme essential for fungal cell wall synthesis. It was approved for the treatment of vulvovaginal candidiasis in adult women, offering an oral alternative to intravenous echinocandin therapies.
Oral antifungal agent targeting fungal cell wall synthesis for the treatment of vulvovaginal candidiasis.
Key facts at a glance
- RxNorm
- 2560215
- Generic
- Ibrexafungerp Citrate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Approved for the treatment of vulvovaginal candidiasis (VVC) in adult women. Clinical trials have also explored its use for other Candida infections and as potential prophylaxis for fungal infections in immunocompromised patients.
Ibrexafungerp inhibits beta-(1,3)-D-glucan synthase, a key enzyme in fungal cell wall synthesis. By blocking this enzyme, it compromises the integrity of the fungal cell wall, leading to cell death. This mechanism is similar to echinocandins but with the advantage of oral bioavailability.
Patients should complete the full prescribed course of therapy. Common side effects may include gastrointestinal symptoms. Drug interactions with certain CYP3A4 inhibitors may occur. Safety in pregnancy has not been established. Always consult current prescribing information for complete safety data.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy