Tenapanor
Ibsrela (tenapanor) is a prescription medication designed to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation in adults. It works locally in the gastrointestinal tract to increase intestinal water secretion and improve bowel movement frequency. The medication is taken orally, typically twice daily before meals.
Ibsrela is a prescription treatment for adults with IBS-C or chronic constipation that works by increasing intestinal fluid to improve bowel movements.
Key facts at a glance
- RxNorm
- 2199680
- Generic
- Ibsrela
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ibsrela is FDA-approved for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults. It helps relieve abdominal discomfort, bloating, and infrequent bowel movements associated with these conditions.
Ibsrela contains the active ingredient tenapanor, which inhibits the sodium/hydrogen exchanger 3 (NHE3) in the intestinal lining. This action reduces sodium absorption, which draws water into the intestines, softening stool and accelerating intestinal transit.
Ibsrela is for adult use only and is not approved for patients under 18 years of age. Common side effects include diarrhea, abdominal distension, flatulence, and dizziness. Patients should stay well-hydrated while taking this medication and should inform their healthcare provider if they have a history of bowel obstruction or are pregnant or breastfeeding.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy