Enasidenib
Idhifa is a targeted therapy medication used to treat adults with relapsed or refractory acute myeloid leukemia (AML) who have a specific genetic mutation called IDH2. It works by inhibiting the mutant IDH2 enzyme to help control cancer cell growth.
Idhifa is a prescription medication for adults with IDH2-mutated AML that has returned or not responded to prior treatment.
Key facts at a glance
- RxNorm
- 1940338
- Generic
- Idhifa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Idhifa is indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. Genetic testing is required to confirm the presence of the IDH2 mutation before starting treatment.
Idhifa is an IDH2 inhibitor that blocks the activity of mutated IDH2 enzymes. In AML with IDH2 mutations, these abnormal enzymes produce high levels of an oncometabolite that promotes the growth and survival of cancer cells. By inhibiting this process, Idhifa helps restore normal cell differentiation.
Idhifa may cause differentiation syndrome, a serious condition that can be life-threatening and requires prompt treatment. Common side effects include nausea, vomiting, diarrhea, decreased appetite, and elevated bilirubin. Patients should be monitored for signs of differentiation syndrome, and healthcare providers should confirm IDH2 mutation status prior to initiating therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy