Dexmedetomidine
Igalmi is a prescription medication used for the acute treatment of mild-to-moderate agitation in adults with schizophrenia or bipolar disorder. It is administered as a sublingual film that dissolves under the tongue, providing relatively rapid symptom relief during episodes of agitation.
Igalmi is a sublingual film medication for the short-term treatment of agitation associated with schizophrenia or bipolar disorder in adults.
Key facts at a glance
- RxNorm
- 2601120
- Generic
- Igalmi
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Igalmi is indicated for the acute treatment of mild-to-moderate agitation in adults with schizophrenia or bipolar I or II disorder. It is not intended for long-term daily use or for patients experiencing severe agitation requiring injectable therapy.
Igalmi contains dexmedetomidine, an alpha-2 adrenergic agonist. It works by binding to alpha-2 receptors in the brain, which reduces sympathetic nervous system activity, resulting in decreased agitation and promoting a calm state.
Common side effects may include drowsiness, dry mouth, and dizziness. Igalmi can cause hypotension and bradycardia, so vital signs should be monitored. Patients should avoid driving or operating machinery until they know how the medication affects them. It should be used as part of a comprehensive treatment plan that may include other medications and psychotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy