Iloperidone
Iloperidone is an atypical antipsychotic medication used to treat schizophrenia in adults. While its exact mechanism of action is unknown, it is believed to work by blocking dopamine D2 receptors and serotonin 5-HT2 receptors in the brain. The body converts iloperidone into an active metabolite that also contributes to its therapeutic effects.
Iloperidone is an oral antipsychotic used to treat schizophrenia in adults by blocking dopamine and serotonin receptors.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05AX14
- RxNorm
- 73178
- Generic
- Iloperidone
- Class
- atc-n05
- Brands
- Fanapt
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Iloperidone is FDA-approved for the acute treatment of schizophrenia in adults. It may also be used for the management of bipolar I disorder.
The exact mechanism is unclear, but iloperidone is thought to work through combined antagonism of dopamine D2 and serotonin 5-HT2 receptors. The drug is metabolized into an active metabolite that contributes to its antipsychotic effects.
Iloperidone is taken orally, typically twice daily. Common side effects include dizziness, drowsiness, dry mouth, and weight gain. Like other antipsychotics, it may cause metabolic changes and requires monitoring. It is not approved for use in elderly patients with dementia-related psychosis due to increased mortality risk.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy