Indapamide
Indapamide is a thiazide-like diuretic that helps the body eliminate excess fluid and salt through increased urination. It is primarily prescribed for the treatment of hypertension (high blood pressure) and edema (fluid retention) associated with conditions such as heart failure.
A diuretic medication used to treat high blood pressure and fluid retention by helping the kidneys remove excess salt and water from the body.
Key facts at a glance
- ATC
- C03BA11
- RxNorm
- 5764
- Generic
- Indapamide
- Class
- atc-c03
- Brands
- Widaplik
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 1.25mg to 2.5mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- Not typically recommended for pediatric patients
- Maximum
- consult physician
- Frequency
- N/A
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 1.25mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
9 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second third trimesteravoid
discontinue use in pregnancy or switch to safer alternative
fetal growth monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingavoid
indapamide is excreted in breast milk; consider alternative therapy
monitor infant for electrolyte disturbances
Use with caution and monitor for adverse effects.
geriatric
elderlystart at low dose
use lower initial dose and titrate slowly; monitor renal function and electrolytes
regular monitoring of renal function, electrolytes, and blood pressure
Use with caution and monitor for adverse effects.
pediatric_age
children adolescentsnot recommended
safety and efficacy not established in pediatric patients
not applicable
Use of this medication in this population requires careful consideration of risks and benefits.
renal_impairment
mild moderatemay need dose reduction
use with caution; monitor renal function and electrolytes
regular monitoring of serum creatinine, potassium, and other electrolytes
Use with caution and monitor for adverse effects.
renal_impairment
severeavoid or use very low dose
use with extreme caution; consider alternative diuretics
frequent monitoring of renal function and electrolytes
Use with caution and monitor for adverse effects.
hepatic_impairment
mild moderateuse with caution
use with caution; may require dose adjustment
monitor electrolytes and liver function
Use with caution and monitor for adverse effects.
hepatic_impairment
severeavoid
avoid use in severe hepatic impairment due to risk of electrolyte imbalance
close monitoring if used
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Mechanism of action
Drug mechanism information
Treatment of essential hypertension (high blood pressure) and management of edema (fluid retention) associated with heart failure, kidney disorders, or other conditions.
Indapamide works by blocking sodium reabsorption in the distal convoluted tubule of the kidney, promoting increased urine output. This reduces fluid volume in the bloodstream, decreasing blood pressure and relieving swelling.
May cause electrolyte imbalances (low potassium, sodium, magnesium) and should be used with caution in patients with kidney or liver disease. Regular monitoring of blood pressure, electrolytes, and kidney function is recommended during treatment.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy