Eplerenone
Inspra (eplerenone) is a potassium-sparing diuretic that works by blocking aldosterone receptors in the kidneys to reduce fluid retention and lower blood pressure. It is primarily prescribed to improve survival in patients with heart failure following a heart attack and to treat hypertension.
Inspra is a potassium-sparing diuretic used to treat heart failure and high blood pressure by blocking aldosterone's effects on fluid and electrolyte balance.
Key facts at a glance
- RxNorm
- 342280
- Generic
- Inspra
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Inspra is approved for reducing the risk of cardiovascular death and hospitalization in patients with systolic heart failure (NYHA Class II-IV) following a heart attack, as well as for treating hypertension as part of a comprehensive blood pressure management plan.
Inspra selectively blocks aldosterone at mineralocorticoid receptors in the kidneys, heart, blood vessels, and brain. This prevents sodium and water reabsorption while preserving potassium excretion, resulting in reduced fluid volume, lower blood pressure, and decreased cardiac workload.
Regular monitoring of potassium levels and kidney function is essential, as hyperkalemia is a serious risk. Contraindicated in patients with severe kidney impairment, type 2 diabetes with proteinuria, or when taking potassium supplements, other potassium-sparing diuretics, or strong CYP3A4 inhibitors. Common side effects may include dizziness, fatigue, and abnormal heart rhythm.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy