Etravirine
Intelence (etravirine) is an antiretroviral medication classified as a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to treat HIV-1 infection in adults and children. It works by inhibiting reverse transcriptase, an essential enzyme that HIV needs to replicate, thereby reducing viral load and allowing the immune system to recover. This medication is typically prescribed for treatment-experienced patients who have developed resistance to other HIV medications.
Intelence is an HIV medication that inhibits viral replication when combined with other antiretrovirals in patients with HIV-1 infection.
Key facts at a glance
- RxNorm
- 758552
- Generic
- Intelence
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of HIV-1 infection in combination with other antiretroviral agents in adults and children (ages 2 and older) who have failed prior therapy, particularly those with viral strains resistant to other NNRTIs and other antiretrovirals.
Intelence is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that works by binding directly to reverse transcriptase and blocking the RNA-dependent and DNA-dependent polymerase activities, preventing the conversion of viral RNA into DNA and interrupting HIV replication.
Take twice daily with food; do not crush tablets. Common side effects include rash (most common in first weeks of therapy), nausea, and diarrhea. Has numerous drug interactions including with certain anticonvulsants, rifamycins, and other antiretrovirals. Severe skin reactions have been reported and require immediate medical attention. Always use in combination with other antiretrovirals; never as monotherapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy