Canagliflozin and Metformin
Invokamet is a prescription combination medication containing canagliflozin and metformin, used to control blood sugar in adults with type 2 diabetes. Canagliflozin is an SGLT2 inhibitor that helps the kidneys remove glucose through urine, while metformin reduces glucose production in the liver and improves the body's insulin response.
Invokamet is a two-drug combination used to manage blood sugar in adults with type 2 diabetes by helping kidneys remove glucose and reducing liver sugar production.
Key facts at a glance
- RxNorm
- 1545151
- Generic
- Invokamet
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Invokamet is indicated to improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. It is typically used when single-agent therapy is insufficient.
Canagliflozin inhibits SGLT2 proteins in the kidneys, reducing glucose reabsorption and increasing urinary glucose excretion. Metformin works by decreasing hepatic glucose production and improving insulin sensitivity in muscle and fat tissues.
Not indicated for type 1 diabetes or diabetic ketoacidosis. Contraindicated in patients with severe renal impairment, metabolic acidosis, or history of lactic acidosis. May cause dehydration, urinary tract infections, and genital fungal infections. Requires regular kidney function monitoring.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy