Ivermectin and Pyrantel
Iverhart Plus is a prescription heartworm preventive medication for dogs that provides broad-spectrum protection against internal parasites. It is administered monthly and is designed for dogs and puppies over a certain age and weight.
Iverhart Plus is a monthly heartworm and intestinal parasite preventive for dogs containing ivermectin and pyrantel.
Key facts at a glance
- RxNorm
- 2733743
- Generic
- Iverhart Plus
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevents heartworm disease caused by Dirofilaria immitis and treats/controls roundworms and hookworms in dogs.
Iverectin works by activating glutamate-gated chloride channels in parasite nervous systems, causing paralysis and death. Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent against intestinal roundworms and hookworms.
Must be prescribed by a veterinarian after heartworm testing is confirmed negative. Some dog breeds with MDR1 gene mutations may be more sensitive to ivermectin. Should be given monthly year-round for optimal protection. Does not protect against tapeworms or other external parasites.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy