Ivermectin
Iwilfin (eflornithine) is a prescription antiparasitic medication used primarily to treat African trypanosomiasis (sleeping sickness), a potentially fatal disease transmitted by tsetse flies. It works by inhibiting parasite growth, allowing the body's immune system to eliminate the infection. While generally well-tolerated, it requires careful monitoring and is typically administered in healthcare settings.
Iwilfin is an antiparasitic medication used to treat African sleeping sickness by inhibiting parasite growth.
Key facts at a glance
- RxNorm
- 2673200
- Generic
- Iwilfin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Iwilfin is indicated for the treatment of African trypanosomiasis (sleeping sickness), specifically the early hemolymphatic stage caused by Trypanosoma brucei gambiense infection. It is used when the disease has not yet crossed the blood-brain barrier.
Iwilfin contains eflornithine, which inhibits ornithine decarboxylase, an enzyme essential for polyamine synthesis in trypanosome parasites. By blocking this pathway, the medication prevents parasite replication and allows the immune system to clear the infection.
Iwilfin is administered intravenously and requires hospitalization. Common side effects include gastrointestinal disturbances, anemia, and seizures. It should be used with caution in patients with impaired kidney or liver function. Treatment must be initiated and supervised by healthcare professionals experienced in managing African sleeping sickness.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy