Ixazomib
Ixazomib is a proteasome inhibitor used to treat multiple myeloma, a cancer of plasma cells. It works by blocking the proteasome pathway in cancer cells, leading to their death. This oral medication is typically used in combination with other drugs for patients who have received prior treatments.
An oral proteasome inhibitor used to treat relapsed or refractory multiple myeloma.
Key facts at a glance
- ATC
- L01XG03
- RxNorm
- 1723735
- Generic
- Ixazomib
- Class
- atc-l01
- Brands
- Ninlaro
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ixazomib is indicated for the treatment of multiple myeloma in patients who have received at least one prior therapy. It is typically used in combination with lenalidomide and dexamethasone.
Ixazomib is a reversible proteasome inhibitor that preferentially binds to and inhibits the chymotrypsin-like activity of the beta 5 subunit of the 20S proteasome. By blocking this pathway, it disrupts protein regulation in cancer cells, leading to apoptosis (programmed cell death).
Ixazomib is taken orally (capsule) once weekly. Common side effects include thrombocytopenia, neutropenia, gastrointestinal symptoms (nausea, diarrhea, vomiting), and peripheral neuropathy. Regular blood count monitoring is required during treatment. Patients should be advised about potential drug interactions and the importance of taking the medication as prescribed.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy