Sitagliptin and Metformin
Janumet is a brand-name combination medication containing sitagliptin and metformin, used to manage blood sugar levels in adults with type 2 diabetes. It is typically prescribed when diet, exercise, and single-agent therapy are insufficient to control blood glucose. This medication is not indicated for type 1 diabetes or diabetic ketoacidosis.
Janumet combines two diabetes medications to help control blood sugar in adults with type 2 diabetes when other approaches are insufficient.
Key facts at a glance
- RxNorm
- 1372738
- Generic
- Janumet
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Janumet is indicated for improving blood sugar control in adults with type 2 diabetes mellitus, particularly when glycemic goals are not achieved with diet and exercise alone, or when already taking the individual components.
Janumet combines two mechanisms: sitagliptin (a DPP-4 inhibitor) works by increasing incretin hormones to stimulate insulin release and reduce glucagon in a glucose-dependent manner, while metformin (a biguanide) decreases liver glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity.
Janumet carries a boxed warning for lactic acidosis, a rare but serious metabolic complication associated with the metformin component. It should not be used in patients with severe kidney impairment, metabolic acidosis, or diabetic ketoacidosis. Common side effects include gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort. The medication should be taken with meals to reduce GI side effects.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy