Lomitapide
Juxtapid (lomitapide) is a prescription medication used to treat homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder characterized by severely elevated LDL cholesterol levels that are difficult to control with diet or standard cholesterol medications. It is typically used in combination with a low-fat diet and other lipid-lowering therapies.
Juxtapid is a specialized cholesterol-lowering medication for patients with homozygous familial hypercholesterolemia, a rare genetic condition causing dangerously high LDL cholesterol.
Key facts at a glance
- RxNorm
- 1364485
- Generic
- Juxtapid
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Juxtapid is indicated for the treatment of homozygous familial hypercholesterolemia (HoFH) in adult patients, in combination with a low-fat diet and other lipid-lowering therapies, to reduce LDL cholesterol, total cholesterol, apolipoprotein B, and non-HDL cholesterol levels.
Juxtapid contains the active ingredient lomitapide, which inhibits microsomal triglyceride transfer protein (MTP). This enzyme is involved in assembling and secreting very-low-density lipoprotein (VLDL) particles in the liver. By inhibiting MTP, Juxtapid reduces the production of VLDL, which subsequently lowers LDL cholesterol levels in the blood.
Juxtapid carries a boxed warning for hepatotoxicity and should not be used in patients with moderate or severe liver impairment, active liver disease, or unexplained persistent elevations in liver enzymes. Common side effects include gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain. Patients should avoid consuming more than 20% of calories from fat during treatment to minimize GI side effects. Regular liver function monitoring is required during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy